Genome-wide patterns of selection in 230 ancient Eurasians

Iain Mathieson (), Iosif Lazaridis, Nadin Rohland, Swapan Mallick, Nick Patterson, Songül Alpaslan Roodenberg, Eadaoin Harney, Kristin Stewardson, Daniel Fernandes, Mario Novak, Kendra Sirak, Cristina Gamba, Eppie R. Jones, Bastien Llamas, Stanislav Dryomov, Joseph Pickrell, Juan Luís Arsuaga, José María Bermúdez de Castro, Eudald Carbonell, Fokke Gerritsen, Aleksandr Khokhlov, Pavel Kuznetsov, Marina Lozano, Harald Meller, Oleg Mochalov, Vyacheslav Moiseyev, Manuel A. Rojo Guerra, Jacob Roodenberg, Josep Maria Vergès, Johannes Krause, Alan Cooper, Kurt W. Alt, Dorcas Brown, David Anthony, Carles Lalueza-Fox, Wolfgang Haak (), Ron Pinhasi () and David Reich ()
Additional contact information
Iain Mathieson: Harvard Medical School
Iosif Lazaridis: Harvard Medical School
Nadin Rohland: Harvard Medical School
Swapan Mallick: Harvard Medical School
Nick Patterson: Broad Institute of MIT and Harvard
Songül Alpaslan Roodenberg: Independent researcher
Eadaoin Harney: Harvard Medical School
Kristin Stewardson: Harvard Medical School
Daniel Fernandes: School of Archaeology and Earth Institute, Belfield, University College Dublin
Mario Novak: School of Archaeology and Earth Institute, Belfield, University College Dublin
Kendra Sirak: School of Archaeology and Earth Institute, Belfield, University College Dublin
Cristina Gamba: School of Archaeology and Earth Institute, Belfield, University College Dublin
Eppie R. Jones: Smurfit Institute of Genetics, Trinity College Dublin
Bastien Llamas: Australian Centre for Ancient DNA, School of Biological Sciences & Environment Institute, University of Adelaide
Stanislav Dryomov: Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences
Joseph Pickrell: Harvard Medical School
Juan Luís Arsuaga: Centro Mixto UCM-ISCIII de Evolución y Comportamiento Humanos
José María Bermúdez de Castro: Centro Nacional de Investigacíon sobre Evolución Humana (CENIEH)
Eudald Carbonell: IPHES. Institut Català de Paleoecologia Humana i Evolució Social, Campus Sescelades-URV
Fokke Gerritsen: Netherlands Institute in Turkey, Istiklal Caddesi, Nur-i Ziya Sokak 5
Aleksandr Khokhlov: Volga State Academy of Social Sciences and Humanities
Pavel Kuznetsov: Volga State Academy of Social Sciences and Humanities
Marina Lozano: IPHES. Institut Català de Paleoecologia Humana i Evolució Social, Campus Sescelades-URV
Harald Meller: State Office for Heritage Management and Archaeology Saxony-Anhalt and State Museum of Prehistory
Oleg Mochalov: Volga State Academy of Social Sciences and Humanities
Vyacheslav Moiseyev: Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RAS
Manuel A. Rojo Guerra: University of Valladolid
Jacob Roodenberg: The Netherlands Institute for the Near East
Josep Maria Vergès: IPHES. Institut Català de Paleoecologia Humana i Evolució Social, Campus Sescelades-URV
Johannes Krause: Max Planck Institute for the Science of Human History
Alan Cooper: Australian Centre for Ancient DNA, School of Biological Sciences & Environment Institute, University of Adelaide
Kurt W. Alt: State Office for Heritage Management and Archaeology Saxony-Anhalt and State Museum of Prehistory
Dorcas Brown: Hartwick College
David Anthony: Hartwick College
Carles Lalueza-Fox: Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)
Wolfgang Haak: Australian Centre for Ancient DNA, School of Biological Sciences & Environment Institute, University of Adelaide
Ron Pinhasi: School of Archaeology and Earth Institute, Belfield, University College Dublin
David Reich: Harvard Medical School

Nature, 2015, vol. 528, issue 7583, 499-503

Abstract: Abstract Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (12)

Downloads: (external link)
https://www.nature.com/articles/nature16152 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:528:y:2015:i:7583:d:10.1038_nature16152

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature16152

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().