Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Caroline A. Lindemans, Marco Calafiore, Anna M. Mertelsmann, Margaret H. O’Connor, Jarrod A. Dudakov, Robert R. Jenq, Enrico Velardi, Lauren F. Young, Odette M. Smith, Gillian Lawrence, Juliet A. Ivanov, Ya-Yuan Fu, Shuichiro Takashima, Guoqiang Hua, Maria L. Martin, Kevin P. O’Rourke, Yuan-Hung Lo, Michal Mokry, Monica Romera-Hernandez, Tom Cupedo, Lukas E. Dow, Edward E. Nieuwenhuis, Noah F. Shroyer, Chen Liu, Richard Kolesnick, Marcel R. M. van den Brink and Alan M. Hanash ()
Additional contact information
Caroline A. Lindemans: Memorial Sloan Kettering Cancer Center
Marco Calafiore: Memorial Sloan Kettering Cancer Center
Anna M. Mertelsmann: Memorial Sloan Kettering Cancer Center
Margaret H. O’Connor: Memorial Sloan Kettering Cancer Center
Jarrod A. Dudakov: Memorial Sloan Kettering Cancer Center
Robert R. Jenq: Memorial Sloan Kettering Cancer Center
Enrico Velardi: Memorial Sloan Kettering Cancer Center
Lauren F. Young: Memorial Sloan Kettering Cancer Center
Odette M. Smith: Memorial Sloan Kettering Cancer Center
Gillian Lawrence: Memorial Sloan Kettering Cancer Center
Juliet A. Ivanov: Memorial Sloan Kettering Cancer Center
Ya-Yuan Fu: Memorial Sloan Kettering Cancer Center
Shuichiro Takashima: Memorial Sloan Kettering Cancer Center
Guoqiang Hua: Memorial Sloan Kettering Cancer Center
Maria L. Martin: Memorial Sloan Kettering Cancer Center
Kevin P. O’Rourke: Memorial Sloan Kettering Cancer Center
Yuan-Hung Lo: Baylor College of Medicine
Michal Mokry: University Medical Center Utrecht
Monica Romera-Hernandez: Erasmus University Medical Center
Tom Cupedo: Erasmus University Medical Center
Lukas E. Dow: Weill Cornell Medicine
Edward E. Nieuwenhuis: University Medical Center Utrecht
Noah F. Shroyer: Baylor College of Medicine
Chen Liu: Immunology and Laboratory Medicine, University of Florida College of Medicine
Richard Kolesnick: Memorial Sloan Kettering Cancer Center
Marcel R. M. van den Brink: Memorial Sloan Kettering Cancer Center
Alan M. Hanash: Memorial Sloan Kettering Cancer Center

Nature, 2015, vol. 528, issue 7583, 560-564

Abstract: Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

Date: 2015
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DOI: 10.1038/nature16460

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