Competition between DNA methylation and transcription factors determines binding of NRF1

Silvia Domcke, Anaïs Flore Bardet, Paul Adrian Ginno, Dominik Hartl, Lukas Burger and Dirk Schübeler ()
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Silvia Domcke: Friedrich Miescher Institute for Biomedical Research
Anaïs Flore Bardet: Friedrich Miescher Institute for Biomedical Research
Paul Adrian Ginno: Friedrich Miescher Institute for Biomedical Research
Dominik Hartl: Friedrich Miescher Institute for Biomedical Research
Lukas Burger: Friedrich Miescher Institute for Biomedical Research
Dirk Schübeler: Friedrich Miescher Institute for Biomedical Research

Nature, 2015, vol. 528, issue 7583, 575-579

Abstract: The relationship between DNA methylation and transcription factor binding was studied across the genome in mouse embryonic stem cells-the study reveals that the transcription factor NRF1 is methylation-sensitive and how physiological binding of NRF1 relies on local removal of DNA methylation.

Date: 2015
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DOI: 10.1038/nature16462

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