Autophagy maintains stemness by preventing senescence

Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, Laura Ortet, Javier Rodríguez-Ubreva, Elena Rebollo, Vanessa Ruiz-Bonilla, Susana Gutarra, Esteban Ballestar, Antonio L. Serrano, Marco Sandri and Pura Muñoz-Cánoves ()
Additional contact information
Laura García-Prat: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Marta Martínez-Vicente: Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute-CIBERNED
Eusebio Perdiguero: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Laura Ortet: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Javier Rodríguez-Ubreva: Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat
Elena Rebollo: Advanced Fluorescence Microscopy Unit, Molecular Biology Institute of Barcelona (IBMB-CSIC)
Vanessa Ruiz-Bonilla: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Susana Gutarra: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Esteban Ballestar: Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat
Antonio L. Serrano: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)
Marco Sandri: University of Padova
Pura Muñoz-Cánoves: Cell Biology Group, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED)

Nature, 2016, vol. 529, issue 7584, 37-42

Abstract: The regenerative properties of muscle stem cells decline with age as the stem cells enter an irreversible state of senescence; a study of mouse muscle stem cells reveals that entry into senescence is an autophagy-dependent process and promoting autophagy in old satellite cells can reverse senescence and restore their regenerative properties in an injury model.

Date: 2016
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DOI: 10.1038/nature16187

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