A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

Joshua Tan, Kathrin Pieper, Luca Piccoli, Abdirahman Abdi, Mathilde Foglierini, Roger Geiger, Claire Maria Tully, David Jarrossay, Francis Maina Ndungu, Juliana Wambua, Philip Bejon, Chiara Silacci Fregni, Blanca Fernandez-Rodriguez, Sonia Barbieri, Siro Bianchi, Kevin Marsh, Vandana Thathy, Davide Corti, Federica Sallusto, Peter Bull () and Antonio Lanzavecchia ()
Additional contact information
Joshua Tan: Institute for Research in Biomedicine, Università della Svizzera Italiana
Kathrin Pieper: Institute for Research in Biomedicine, Università della Svizzera Italiana
Luca Piccoli: Institute for Research in Biomedicine, Università della Svizzera Italiana
Abdirahman Abdi: KEMRI-Wellcome Trust Research Programme, CGMRC
Mathilde Foglierini: Institute for Research in Biomedicine, Università della Svizzera Italiana
Roger Geiger: Institute for Research in Biomedicine, Università della Svizzera Italiana
Claire Maria Tully: KEMRI-Wellcome Trust Research Programme, CGMRC
David Jarrossay: Institute for Research in Biomedicine, Università della Svizzera Italiana
Francis Maina Ndungu: KEMRI-Wellcome Trust Research Programme, CGMRC
Juliana Wambua: KEMRI-Wellcome Trust Research Programme, CGMRC
Philip Bejon: KEMRI-Wellcome Trust Research Programme, CGMRC
Chiara Silacci Fregni: Institute for Research in Biomedicine, Università della Svizzera Italiana
Blanca Fernandez-Rodriguez: Institute for Research in Biomedicine, Università della Svizzera Italiana
Sonia Barbieri: Institute for Research in Biomedicine, Università della Svizzera Italiana
Siro Bianchi: Humabs BioMed SA
Kevin Marsh: KEMRI-Wellcome Trust Research Programme, CGMRC
Vandana Thathy: KEMRI-Wellcome Trust Research Programme, CGMRC
Davide Corti: Humabs BioMed SA
Federica Sallusto: Institute for Research in Biomedicine, Università della Svizzera Italiana
Peter Bull: KEMRI-Wellcome Trust Research Programme, CGMRC
Antonio Lanzavecchia: Institute for Research in Biomedicine, Università della Svizzera Italiana

Nature, 2016, vol. 529, issue 7584, 105-109

Abstract: Monoclonal antibodies with broad reactivity against antigens on the parasite that causes malaria, Plasmodium falciparum, are isolated from two subjects and are found to have an unusual insertion of an immunoglobulin-like domain from a different chromosome, illustrating a new mechanism of antibody diversification.

Date: 2016
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DOI: 10.1038/nature16450

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