Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Elaine E. Storm, Steffen Durinck, Felipe de Sousa e Melo, Jarrod Tremayne, Noelyn Kljavin, Christine Tan, Xiaofen Ye, Cecilia Chiu, Thinh Pham, Jo-Anne Hongo, Travis Bainbridge, Ron Firestein, Elizabeth Blackwood, Ciara Metcalfe, Eric W. Stawiski, Robert L. Yauch, Yan Wu and Frederic J. de Sauvage ()
Additional contact information
Elaine E. Storm: Molecular Oncology, Genentech, Inc.
Steffen Durinck: Molecular Biology, Genentech, Inc.
Felipe de Sousa e Melo: Molecular Oncology, Genentech, Inc.
Jarrod Tremayne: Translational Oncology, Genentech, Inc.
Noelyn Kljavin: Molecular Oncology, Genentech, Inc.
Christine Tan: Antibody Engineering, Genentech, Inc.
Xiaofen Ye: Discovery Oncology, Genentech, Inc.
Cecilia Chiu: Antibody Engineering, Genentech, Inc.
Thinh Pham: Research Pathology, Genentech, Inc.
Jo-Anne Hongo: Antibody Engineering, Genentech, Inc.
Travis Bainbridge: Protein Chemistry, Genentech, Inc.
Ron Firestein: Research Pathology, Genentech, Inc.
Elizabeth Blackwood: Translational Oncology, Genentech, Inc.
Ciara Metcalfe: Translational Oncology, Genentech, Inc.
Eric W. Stawiski: Molecular Biology, Genentech, Inc.
Robert L. Yauch: Discovery Oncology, Genentech, Inc.
Yan Wu: Antibody Engineering, Genentech, Inc.
Frederic J. de Sauvage: Molecular Oncology, Genentech, Inc.

Nature, 2016, vol. 529, issue 7584, 97-100

Abstract: Antibody-mediated inhibition of R-spondin-3 in colorectal tumours decreases tumour growth and promotes differentiation—these effects are associated with a decrease in expression of genes associated with stem-cell function.

Date: 2016
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DOI: 10.1038/nature16466

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