The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

Rachel Kaletsky, Vanisha Lakhina, Rachel Arey, April Williams, Jessica Landis, Jasmine Ashraf and Coleen T. Murphy ()
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Rachel Kaletsky: Princeton University
Vanisha Lakhina: Princeton University
Rachel Arey: Princeton University
April Williams: Princeton University
Jessica Landis: Princeton University
Jasmine Ashraf: Princeton University
Coleen T. Murphy: Princeton University

Nature, 2016, vol. 529, issue 7584, 92-96

Abstract: The FOXO transcription factor, DAF-16, is required for the long-life phenotype of daf-2 mutant nematode worms; here the authors find that daf-2 mutant worms maintain neuronal functions and behaviours with age by using a set of transcriptional targets that are distinct from previously identified canonical FOXO/DAF-16-regulated targets.

Date: 2016
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DOI: 10.1038/nature16483

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