Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Eric J. Drake, Bradley R. Miller, Ce Shi, Jeffrey T. Tarrasch, Jesse A. Sundlov, C. Leigh Allen, Georgios Skiniotis, Courtney C. Aldrich and Andrew M. Gulick ()
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Eric J. Drake: Hauptman-Woodward Medical Research Institute
Bradley R. Miller: Hauptman-Woodward Medical Research Institute
Ce Shi: University of Minnesota
Jeffrey T. Tarrasch: University of Michigan
Jesse A. Sundlov: Hauptman-Woodward Medical Research Institute
C. Leigh Allen: Hauptman-Woodward Medical Research Institute
Georgios Skiniotis: University of Michigan
Courtney C. Aldrich: University of Minnesota
Andrew M. Gulick: Hauptman-Woodward Medical Research Institute

Nature, 2016, vol. 529, issue 7585, 235-238

Abstract: X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate novel products through engineering enzyme activity.

Date: 2016
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DOI: 10.1038/nature16163

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