Iron-catalysed tritiation of pharmaceuticals

Renyuan Pony Yu, David Hesk, Nelo Rivera, István Pelczer and Paul J. Chirik ()
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Renyuan Pony Yu: Princeton University
David Hesk: Merck Research Laboratories
Nelo Rivera: Merck Research Laboratories
István Pelczer: Princeton University
Paul J. Chirik: Princeton University

Nature, 2016, vol. 529, issue 7585, 195-199

Abstract: An iron-catalysed method for the direct 3H labelling of pharmaceuticals by hydrogen isotope exchange using tritium gas is reported; the site selectivity of the iron catalyst is orthogonal to currently used iridium catalysts and allows isotopic labelling of complementary positions in drug molecules.

Date: 2016
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DOI: 10.1038/nature16464

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