FOXO1 couples metabolic activity and growth state in the vascular endothelium

Kerstin Wilhelm, Katharina Happel, Guy Eelen, Sandra Schoors, Mark F. Oellerich, Radiance Lim, Barbara Zimmermann, Irene M. Aspalter, Claudio A. Franco, Thomas Boettger, Thomas Braun, Marcus Fruttiger, Klaus Rajewsky, Charles Keller, Jens C. Brüning, Holger Gerhardt, Peter Carmeliet and Michael Potente ()
Additional contact information
Kerstin Wilhelm: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
Katharina Happel: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
Guy Eelen: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
Sandra Schoors: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
Mark F. Oellerich: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
Radiance Lim: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
Barbara Zimmermann: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
Irene M. Aspalter: Vascular Biology Laboratory, London Research Institute, Cancer Research UK
Claudio A. Franco: Vascular Morphogenesis Laboratory, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
Thomas Boettger: Max Planck Institute for Heart and Lung Research
Thomas Braun: Max Planck Institute for Heart and Lung Research
Marcus Fruttiger: UCL Institute of Ophthalmology, University College London
Klaus Rajewsky: Max Delbrück Center for Molecular Medicine (MDC)
Charles Keller: Children’s Cancer Therapy Development Institute
Jens C. Brüning: Max Planck Institute for Metabolism Research, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University of Cologne
Holger Gerhardt: Vascular Biology Laboratory, London Research Institute, Cancer Research UK
Peter Carmeliet: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven
Michael Potente: Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research

Nature, 2016, vol. 529, issue 7585, 216-220

Abstract: The transcription factor FOXO1 is identified as a crucial checkpoint of vascular growth, coupling the metabolic and proliferative activities of endothelial cells.

Date: 2016
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DOI: 10.1038/nature16498

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