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Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

Janice M. Reimer, Martin N. Aloise, Paul M. Harrison and T. Martin Schmeing ()
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Janice M. Reimer: McGill University
Martin N. Aloise: McGill University
Paul M. Harrison: McGill University
T. Martin Schmeing: McGill University

Nature, 2016, vol. 529, issue 7585, 239-242

Abstract: WebX-ray crystal structures are presented of each major step of the assembly-line synthesis by the initiation module of the nonribosomal peptide synthetase (NRPS) LgrA; the structures reveal large conformational changes, demonstrating a requirement for NRPSs to be very dynamic.

Date: 2016
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DOI: 10.1038/nature16503

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