Diet-induced extinctions in the gut microbiota compound over generations

Erica D. Sonnenburg, Samuel A. Smits, Mikhail Tikhonov, Steven K. Higginbottom, Ned S. Wingreen and Justin L. Sonnenburg ()
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Erica D. Sonnenburg: Stanford University School of Medicine
Samuel A. Smits: Stanford University School of Medicine
Mikhail Tikhonov: Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University
Steven K. Higginbottom: Stanford University School of Medicine
Ned S. Wingreen: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Justin L. Sonnenburg: Stanford University School of Medicine

Nature, 2016, vol. 529, issue 7585, 212-215

Abstract: In mice on a low microbiota-accessible carbohydrate (MAC) diet, the diversity of the gut microbiota is depleted, and the effect is transferred and compounded over generations; this phenotype is only reversed after supplementation of the missing taxa via faecal microbiota transplantation, suggesting dietary intervention alone may by insufficient at managing diseases characterized by a dysbiotic microbiota.

Date: 2016
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DOI: 10.1038/nature16504

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