Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

François Gerbe, Emmanuelle Sidot, Danielle J. Smyth, Makoto Ohmoto, Ichiro Matsumoto, Valérie Dardalhon, Pierre Cesses, Laure Garnier, Marie Pouzolles, Bénédicte Brulin, Marco Bruschi, Yvonne Harcus, Valérie S. Zimmermann, Naomi Taylor, Rick M. Maizels and Philippe Jay ()
Additional contact information
François Gerbe: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Emmanuelle Sidot: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Danielle J. Smyth: Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh
Makoto Ohmoto: Monell Chemical Senses Center
Ichiro Matsumoto: Monell Chemical Senses Center
Valérie Dardalhon: Université de Montpellier
Pierre Cesses: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Laure Garnier: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Marie Pouzolles: Université de Montpellier
Bénédicte Brulin: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Marco Bruschi: CNRS, UMR-5203, Institut de Génomique Fonctionnelle
Yvonne Harcus: Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh
Valérie S. Zimmermann: Université de Montpellier
Naomi Taylor: Université de Montpellier
Rick M. Maizels: Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh
Philippe Jay: CNRS, UMR-5203, Institut de Génomique Fonctionnelle

Nature, 2016, vol. 529, issue 7585, 226-230

Abstract: Epithelial tuft cells secretion of IL-25 is shown to regulate type 2 epithelial responses to helminth parasite infection via an IL-13/IL-4Rα-dependent feedback loop.

Date: 2016
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DOI: 10.1038/nature16527

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