Divergent clonal selection dominates medulloblastoma at recurrence

A. Sorana Morrissy, Livia Garzia, David J. H. Shih, Scott Zuyderduyn, Xi Huang, Patryk Skowron, Marc Remke, Florence M. G. Cavalli, Vijay Ramaswamy, Patricia E. Lindsay, Salomeh Jelveh, Laura K. Donovan, Xin Wang, Betty Luu, Kory Zayne, Yisu Li, Chelsea Mayoh, Nina Thiessen, Eloi Mercier, Karen L. Mungall, Yusanne Ma, Kane Tse, Thomas Zeng, Karey Shumansky, Andrew J. L. Roth, Sohrab Shah, Hamza Farooq, Noriyuki Kijima, Borja L. Holgado, John J. Y. Lee, Stuart Matan-Lithwick, Jessica Liu, Stephen C. Mack, Alex Manno, K. A. Michealraj, Carolina Nor, John Peacock, Lei Qin, Juri Reimand, Adi Rolider, Yuan Y. Thompson, Xiaochong Wu, Trevor Pugh, Adrian Ally, Mikhail Bilenky, Yaron S. N. Butterfield, Rebecca Carlsen, Young Cheng, Eric Chuah, Richard D. Corbett, Noreen Dhalla, An He, Darlene Lee, Haiyan I. Li, William Long, Michael Mayo, Patrick Plettner, Jenny Q. Qian, Jacqueline E. Schein, Angela Tam, Tina Wong, Inanc Birol, Yongjun Zhao, Claudia C. Faria, José Pimentel, Sofia Nunes, Tarek Shalaby, Michael Grotzer, Ian F. Pollack, Ronald L. Hamilton, Xiao-Nan Li, Anne E. Bendel, Daniel W. Fults, Andrew W. Walter, Toshihiro Kumabe, Teiji Tominaga, V. Peter Collins, Yoon-Jae Cho, Caitlin Hoffman, David Lyden, Jeffrey H. Wisoff, James H. Garvin, Duncan S. Stearns, Luca Massimi, Ulrich Schüller, Jaroslav Sterba, Karel Zitterbart, Stephanie Puget, Olivier Ayrault, Sandra E. Dunn, Daniela P. C. Tirapelli, Carlos G. Carlotti, Helen Wheeler, Andrew R. Hallahan, Wendy Ingram, Tobey J. MacDonald, Jeffrey J. Olson, Erwin G. Van Meir, Ji-Yeoun Lee, Kyu-Chang Wang, Seung-Ki Kim, Byung-Kyu Cho, Torsten Pietsch, Gudrun Fleischhack, Stephan Tippelt, Young Shin Ra, Simon Bailey, Janet C. Lindsey, Steven C. Clifford, Charles G. Eberhart, Michael K. Cooper, Roger J. Packer, Maura Massimino, Maria Luisa Garre, Ute Bartels, Uri Tabori, Cynthia E. Hawkins, Peter Dirks, Eric Bouffet, James T. Rutka, Robert J. Wechsler-Reya, William A. Weiss, Lara S. Collier, Adam J. Dupuy, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Stefan M. Pfister, David A. Largaespada, Andrew J. Mungall, Richard A. Moore, Nada Jabado, Gary D. Bader, Steven J. M. Jones, David Malkin, Marco A. Marra () and Michael D. Taylor ()
Additional contact information
A. Sorana Morrissy: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Livia Garzia: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
David J. H. Shih: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Scott Zuyderduyn: The Donnelly Centre, University of Toronto
Xi Huang: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Patryk Skowron: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Marc Remke: Hematology, and Clinical Immunology, University Hospital Düsseldorf
Florence M. G. Cavalli: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Vijay Ramaswamy: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Patricia E. Lindsay: University of Toronto
Salomeh Jelveh: Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network
Laura K. Donovan: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Xin Wang: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Betty Luu: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Kory Zayne: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Yisu Li: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Chelsea Mayoh: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Nina Thiessen: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Eloi Mercier: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Karen L. Mungall: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Yusanne Ma: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Kane Tse: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Thomas Zeng: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Karey Shumansky: BC Cancer Agency
Andrew J. L. Roth: BC Cancer Agency
Sohrab Shah: BC Cancer Agency
Hamza Farooq: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Noriyuki Kijima: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Borja L. Holgado: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
John J. Y. Lee: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Stuart Matan-Lithwick: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Jessica Liu: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Stephen C. Mack: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Alex Manno: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
K. A. Michealraj: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Carolina Nor: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
John Peacock: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Lei Qin: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Juri Reimand: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Adi Rolider: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Yuan Y. Thompson: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Xiaochong Wu: Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Trevor Pugh: Clinical Genomics Research Program, Princess Margaret Cancer Centre, University Health Network
Adrian Ally: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Mikhail Bilenky: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Yaron S. N. Butterfield: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Rebecca Carlsen: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Young Cheng: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Eric Chuah: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Richard D. Corbett: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Noreen Dhalla: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
An He: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Darlene Lee: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Haiyan I. Li: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
William Long: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Michael Mayo: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Patrick Plettner: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Jenny Q. Qian: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Jacqueline E. Schein: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Angela Tam: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Tina Wong: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Inanc Birol: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Yongjun Zhao: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Claudia C. Faria: Centro Hospitalar Lisboa Norte, Hospital de Santa Maria
José Pimentel: Divison of Pathology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria
Sofia Nunes: Unidade de Neuro-Oncologia Pediátrica, Instituto Português de Oncologia de Lisboa Francisco Gentil
Tarek Shalaby: University Children’s Hospital of Zurich
Michael Grotzer: University Children’s Hospital of Zurich
Ian F. Pollack: University of Pittsburgh School of Medicine
Ronald L. Hamilton: University of Pittsburgh School of Medicine
Xiao-Nan Li: Brain Tumor Program, Baylor College of Medicine
Anne E. Bendel: Pediatric Hematology-Oncology, Children’s Hospitals and Clinics of Minnesota
Daniel W. Fults: Clinical Neurosciences Center, University of Utah, Salt Lake City
Andrew W. Walter: A I duPont Hospital for Children
Toshihiro Kumabe: Kitasato University School of Medicine
Teiji Tominaga: Tohoku University Graduate School of Medicine
V. Peter Collins: University of Cambridge
Yoon-Jae Cho: Neurology and Neurological Sciences, Stanford University School of Medicine
Caitlin Hoffman: The Hospital for Sick Children
David Lyden: Cell & Developmental Biology, Weill Medical College of Cornell University
Jeffrey H. Wisoff: NYU Langone Medical Center
James H. Garvin: Oncology, and Stem Cell Transplantation, Columbia University
Duncan S. Stearns: Case Western Reserve
Luca Massimi: Pediatric Neurosurgery, Catholic University Medical School
Ulrich Schüller: Center for Neuropathology, Ludwig-Maximilians-Universität
Jaroslav Sterba: School of Medicine, Masaryk University
Karel Zitterbart: School of Medicine, Masaryk University
Stephanie Puget: AP-HP, Necker-Enfants Malades Hospital, Université René Descartes
Olivier Ayrault: Signaling in Development and Brain Tumors, CNRS UMR 3347 / INSERM U1021, Institut Curie
Sandra E. Dunn: British Columbia Children’s Hospital
Daniela P. C. Tirapelli: Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Brazil
Carlos G. Carlotti: Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Brazil
Helen Wheeler: Kolling Institute of Medical Research, The University of Sydney
Andrew R. Hallahan: Queensland Children's Medical Research Institute, Children’s Health Queensland
Wendy Ingram: Queensland Children's Medical Research Institute, Children’s Health Queensland
Tobey J. MacDonald: Pediatric Neuro-Oncology Program, School of Medicine and Winship Cancer Institute, Emory University
Jeffrey J. Olson: School of Medicine and Winship Cancer Institute, Emory University
Erwin G. Van Meir: School of Medicine and Winship Cancer Institute, Emory University
Ji-Yeoun Lee: Seoul National University Children’s Hospital
Kyu-Chang Wang: Seoul National University Children’s Hospital
Seung-Ki Kim: Seoul National University Children’s Hospital
Byung-Kyu Cho: Seoul National University Children’s Hospital
Torsten Pietsch: Institute for Neuropathology, University of Bonn D-53105
Gudrun Fleischhack: Children’s University Hospital of Essen D-45147
Stephan Tippelt: Children’s University Hospital of Essen D-45147
Young Shin Ra: University of Ulsan, Asan Medical Center
Simon Bailey: Northern Institute for Cancer Research, Newcastle University
Janet C. Lindsey: Northern Institute for Cancer Research, Newcastle University
Steven C. Clifford: Northern Institute for Cancer Research, Newcastle University
Charles G. Eberhart: Ophthalmology and Oncology, John Hopkins University School of Medicine
Michael K. Cooper: Department of Neurology
Roger J. Packer: Children’s National Medical Center
Maura Massimino: Fondazione IRCCS Istituto Nazionale Tumori
Maria Luisa Garre: U.O. Neurochirurgia, Istituto Giannina Gaslini
Ute Bartels: The Hospital for Sick Children
Uri Tabori: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Cynthia E. Hawkins: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Peter Dirks: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Eric Bouffet: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
James T. Rutka: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Robert J. Wechsler-Reya: Sanford-Burnham Medical Research Institute
William A. Weiss: Neurology and Neurosurgery, University of California San Francisco
Lara S. Collier: School of Pharmacology, University of Wisconsin
Adam J. Dupuy: Molecular & Cellular Biology Program, University of Iowa, Iowa City
Andrey Korshunov: Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ)
David T. W. Jones: German Cancer Research Center (DKFZ)
Marcel Kool: German Cancer Research Center (DKFZ)
Paul A. Northcott: German Cancer Research Center (DKFZ)
Stefan M. Pfister: German Cancer Research Center (DKFZ)
David A. Largaespada: Masonic Cancer Center, University of Minnesota
Andrew J. Mungall: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Richard A. Moore: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Nada Jabado: McGill University
Gary D. Bader: The Donnelly Centre, University of Toronto
Steven J. M. Jones: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
David Malkin: The Hospital for Sick Children
Marco A. Marra: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Michael D. Taylor: Developmental & Stem Cell Biology Program, The Hospital for Sick Children

Nature, 2016, vol. 529, issue 7586, 351-357

Abstract: Abstract The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional genomic mouse model of medulloblastoma with ‘humanized’ in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (

Date: 2016
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DOI: 10.1038/nature16478

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