NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

Kazuhiro Murakami, Ufuk Günesdogan, Jan J. Zylicz, Walfred W. C. Tang, Roopsha Sengupta, Toshihiro Kobayashi, Shinseog Kim, Richard Butler, Sabine Dietmann and M. Azim Surani ()
Additional contact information
Kazuhiro Murakami: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Ufuk Günesdogan: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Jan J. Zylicz: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Walfred W. C. Tang: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Roopsha Sengupta: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Toshihiro Kobayashi: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Shinseog Kim: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Richard Butler: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Sabine Dietmann: Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,
M. Azim Surani: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

Nature, 2016, vol. 529, issue 7586, 403-407

Abstract: In mouse embryonic stem cells converted to an epiblast fate in vitro—a state in which the cells can also gain germ cell fate if exposed to the signalling molecule BMP4—the sole expression of the transcription factor NANOG is shown to be sufficient to induce germ cell fate, in the absence of BMP4.

Date: 2016
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DOI: 10.1038/nature16480

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