Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

Alistair N. Boettiger, Bogdan Bintu, Jeffrey R. Moffitt, Siyuan Wang, Brian J. Beliveau, Geoffrey Fudenberg, Maxim Imakaev, Leonid A. Mirny, Chao-ting Wu and Xiaowei Zhuang ()
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Alistair N. Boettiger: Howard Hughes Medical Institute, Harvard University
Bogdan Bintu: Howard Hughes Medical Institute, Harvard University
Jeffrey R. Moffitt: Howard Hughes Medical Institute, Harvard University
Siyuan Wang: Howard Hughes Medical Institute, Harvard University
Brian J. Beliveau: Harvard Medical School
Geoffrey Fudenberg: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Maxim Imakaev: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Leonid A. Mirny: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Chao-ting Wu: Harvard Medical School
Xiaowei Zhuang: Howard Hughes Medical Institute, Harvard University

Nature, 2016, vol. 529, issue 7586, 418-422

Abstract: Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find that transcriptionally active, inactive and Polycomb-repressed chromatin states each have a distinct spatial organisation.

Date: 2016
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DOI: 10.1038/nature16496

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