Antibacterial drug discovery in the resistance era

Eric D. Brown () and Gerard D. Wright ()
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Eric D. Brown: Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
Gerard D. Wright: Michael G. DeGroote Institute for Infectious Disease Research, McMaster University

Nature, 2016, vol. 529, issue 7586, 336-343

Abstract: Abstract The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.

Date: 2016
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DOI: 10.1038/nature17042

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