The domestication of Cas9

Fyodor Urnov ()
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Fyodor Urnov: Fyodor Urnov is at Sangamo BioSciences, Richmond, California 94804, USA.

Nature, 2016, vol. 529, issue 7587, 468-469

Abstract: The enzyme Cas9 is used in genome editing to cut selected DNA sequences, but it also creates breaks at off-target sites. Protein engineering has now been used to make Cas9 enzymes that have minimal off-target effects. See Article p.490

Date: 2016
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DOI: 10.1038/529468a

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