Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

Chong T. Luo, Will Liao, Saida Dadi, Ahmed Toure and Ming O. Li ()
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Chong T. Luo: Immunology Program, Memorial Sloan Kettering Cancer Center
Will Liao: New York Genome Center
Saida Dadi: Immunology Program, Memorial Sloan Kettering Cancer Center
Ahmed Toure: Immunology Program, Memorial Sloan Kettering Cancer Center
Ming O. Li: Immunology Program, Memorial Sloan Kettering Cancer Center

Nature, 2016, vol. 529, issue 7587, 532-536

Abstract: The transcription factor Foxo1 is shown to be involved in the determination of distinct subsets of regulatory T (Treg) cells, and the differentiation of activated phenotype Treg cells is associated with the repression of the Foxo1-dependent transcriptional program; constitutively active Foxo1 expression triggers depletion of activated Treg cells in peripheral tissues and leads to CD8 T-cell-mediated autoimmunity and anti-tumour immunity.

Date: 2016
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DOI: 10.1038/nature16486

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