Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

Larry L. Luchsinger, Mariana Justino de Almeida, David J. Corrigan, Melanie Mumau and Hans-Willem Snoeck ()
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Larry L. Luchsinger: Columbia Center for Translational Immunology, Columbia University Medical Center
Mariana Justino de Almeida: Columbia Center for Translational Immunology, Columbia University Medical Center
David J. Corrigan: Columbia Center for Translational Immunology, Columbia University Medical Center
Melanie Mumau: Columbia Center for Translational Immunology, Columbia University Medical Center
Hans-Willem Snoeck: Columbia Center for Translational Immunology, Columbia University Medical Center

Nature, 2016, vol. 529, issue 7587, 528-531

Abstract: The role of mitochondria in haematopoietic stem-cell maintenance has not been examined in detail; here mitofusin 2, which modulates mitochondrial fusion and tethering of endoplasmic reticulum to the mitochondria, is shown to be necessary for the maintenance of haematopoietic stem cells with extensive lymphoid potential.

Date: 2016
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DOI: 10.1038/nature16500

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