Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

Nicola B. Hamilton (), Karolina Kolodziejczyk, Eleni Kougioumtzidou and David Attwell ()
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Nicola B. Hamilton: Physiology & Pharmacology, University College London
Karolina Kolodziejczyk: Physiology & Pharmacology, University College London
Eleni Kougioumtzidou: Physiology & Pharmacology, University College London
David Attwell: Physiology & Pharmacology, University College London

Nature, 2016, vol. 529, issue 7587, 523-527

Abstract: Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is caused through the H+-dependent activation of TRPA1 channels, and not via glutamate receptors of the NMDA type, as previously thought, providing a new mechanism and promising therapeutic targets for diseases as diverse and prevalent as cerebral palsy, spinal cord injury, stroke and multiple sclerosis.

Date: 2016
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DOI: 10.1038/nature16519

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