Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Faranak Fattahi, Julius A Steinbeck, Sonja Kriks, Jason Tchieu, Bastian Zimmer, Sarah Kishinevsky, Nadja Zeltner, Yvonne Mica, Wael El-Nachef, Huiyong Zhao, Elisa de Stanchina, Michael D. Gershon, Tracy C. Grikscheit, Shuibing Chen and Lorenz Studer ()
Additional contact information
Faranak Fattahi: The Center for Stem Cell Biology
Julius A Steinbeck: The Center for Stem Cell Biology
Sonja Kriks: The Center for Stem Cell Biology
Jason Tchieu: The Center for Stem Cell Biology
Bastian Zimmer: The Center for Stem Cell Biology
Sarah Kishinevsky: The Center for Stem Cell Biology
Nadja Zeltner: The Center for Stem Cell Biology
Yvonne Mica: The Center for Stem Cell Biology
Wael El-Nachef: Molecular Pharmacology Program
Huiyong Zhao: Molecular Pharmacology Program
Elisa de Stanchina: Molecular Pharmacology Program
Michael D. Gershon: Columbia University, College of Physicians and Surgeons
Tracy C. Grikscheit: Children’s Hospital Los Angeles, Pediatric Surgery
Shuibing Chen: Weill Medical College of Cornell University
Lorenz Studer: The Center for Stem Cell Biology

Nature, 2016, vol. 531, issue 7592, 105-109

Abstract: A differentiation protocol to obtain enteric nervous system (ENS) progenitors and a range of neurons from human pluripotent stem cells is developed; the cells can migrate and graft to the colon of a chick embryo and an adult mouse colon, including in a mouse model of Hirschsprung disease, in which a functional rescue is observed.

Date: 2016
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DOI: 10.1038/nature16951

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