Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

Alexandra C. Walls, M. Alejandra Tortorici, Berend-Jan Bosch, Brandon Frenz, Peter J. M. Rottier, Frank DiMaio, Félix A. Rey () and David Veesler ()
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Alexandra C. Walls: University of Washington
M. Alejandra Tortorici: Institut Pasteur, Unité de Virologie
Berend-Jan Bosch: Faculty of Veterinary Medicine, Utrecht University
Brandon Frenz: University of Washington
Peter J. M. Rottier: Faculty of Veterinary Medicine, Utrecht University
Frank DiMaio: University of Washington
Félix A. Rey: Institut Pasteur, Unité de Virologie
David Veesler: University of Washington

Nature, 2016, vol. 531, issue 7592, 114-117

Abstract: The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals architectural similarities to paramyxovirus F proteins, suggesting that these fusion proteins may have evolved from a distant common ancestor.

Date: 2016
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DOI: 10.1038/nature16988

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