Palladium-catalysed transannular C–H functionalization of alicyclic amines

Joseph J. Topczewski, Pablo J. Cabrera, Noam I. Saper and Melanie S. Sanford ()
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Joseph J. Topczewski: University of Michigan, 930 North University Avenue
Pablo J. Cabrera: University of Michigan, 930 North University Avenue
Noam I. Saper: University of Michigan, 930 North University Avenue
Melanie S. Sanford: University of Michigan, 930 North University Avenue

Nature, 2016, vol. 531, issue 7593, 220-224

Abstract: An approach to selectively manipulate the C–H bonds of alicyclic amines at sites remote to nitrogen is demonstrated by the synthesis of new derivatives of several bioactive molecules, including varenicline, a drug used to treat nicotine addiction.

Date: 2016
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DOI: 10.1038/nature16957

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