NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Chi Ma, Aparna H. Kesarwala, Tobias Eggert, José Medina-Echeverz, David E. Kleiner, Ping Jin, David F. Stroncek, Masaki Terabe, Veena Kapoor, Mei ElGindi, Miaojun Han, Angela M. Thornton, Haibo Zhang, Michèle Egger, Ji Luo, Dean W. Felsher, Daniel W. McVicar, Achim Weber, Mathias Heikenwalder and Tim F. Greten ()
Additional contact information
Chi Ma: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Aparna H. Kesarwala: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health
Tobias Eggert: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
José Medina-Echeverz: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
David E. Kleiner: Laboratory of Pathology, National Cancer Institute, National Institutes of Health
Ping Jin: Cell Processing Section, Clinical Center, National Institutes of Health
David F. Stroncek: Cell Processing Section, Clinical Center, National Institutes of Health
Masaki Terabe: Vaccine Branch, National Cancer Institute, National Institutes of Health
Veena Kapoor: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health
Mei ElGindi: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Miaojun Han: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Angela M. Thornton: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Haibo Zhang: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
Michèle Egger: Institute of Surgical Pathology, University and University Hospital Zurich
Ji Luo: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
Dean W. Felsher: Stanford University
Daniel W. McVicar: Cancer and Inflammation Program, National Cancer Institute
Achim Weber: Institute of Surgical Pathology, University and University Hospital Zurich
Mathias Heikenwalder: Institute of Virology, Technische Universität München/Helmholtz Zentrum München,
Tim F. Greten: Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health

Nature, 2016, vol. 531, issue 7593, 253-257

Abstract: Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4+ T cells, leading to impaired anti-tumour immunity.

Date: 2016
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DOI: 10.1038/nature16969

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