Co-ordinated ocular development from human iPS cells and recovery of corneal function

Ryuhei Hayashi, Yuki Ishikawa, Yuzuru Sasamoto, Ryosuke Katori, Naoki Nomura, Tatsuya Ichikawa, Saori Araki, Takeshi Soma, Satoshi Kawasaki, Kiyotoshi Sekiguchi, Andrew J. Quantock, Motokazu Tsujikawa and Kohji Nishida ()
Additional contact information
Ryuhei Hayashi: Osaka University Graduate School of Medicine
Yuki Ishikawa: Osaka University Graduate School of Medicine
Yuzuru Sasamoto: Osaka University Graduate School of Medicine
Ryosuke Katori: Osaka University Graduate School of Medicine
Naoki Nomura: Osaka University Graduate School of Medicine
Tatsuya Ichikawa: Osaka University Graduate School of Medicine
Saori Araki: Osaka University Graduate School of Medicine
Takeshi Soma: Osaka University Graduate School of Medicine
Satoshi Kawasaki: Osaka University Graduate School of Medicine
Kiyotoshi Sekiguchi: Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University
Andrew J. Quantock: Structural Biophysics Group, School of Optometry and Vision Sciences, College of Biomedical and Life Sciences, Cardiff University
Motokazu Tsujikawa: Osaka University Graduate School of Medicine
Kohji Nishida: Osaka University Graduate School of Medicine

Nature, 2016, vol. 531, issue 7594, 376-380

Abstract: A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.

Date: 2016
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DOI: 10.1038/nature17000

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