Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo, Adrian S. Ray, Richard L. Mackman, Veronica Soloveva, Dustin Siegel, Michel Perron, Roy Bannister, Hon C. Hui, Nate Larson, Robert Strickley, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Amy C. Shurtleff, Cary J. Retterer, Dima Gharaibeh, Rouzbeh Zamani, Tara Kenny, Brett P. Eaton, Elizabeth Grimes, Lisa S. Welch, Laura Gomba, Catherine L. Wilhelmsen, Donald K. Nichols, Jonathan E. Nuss, Elyse R. Nagle, Jeffrey R. Kugelman, Gustavo Palacios, Edward Doerffler, Sean Neville, Ernest Carra, Michael O. Clarke, Lijun Zhang, Willard Lew, Bruce Ross, Queenie Wang, Kwon Chun, Lydia Wolfe, Darius Babusis, Yeojin Park, Kirsten M. Stray, Iva Trancheva, Joy Y. Feng, Ona Barauskas, Yili Xu, Pamela Wong, Molly R. Braun, Mike Flint, Laura K. McMullan, Shan-Shan Chen, Rachel Fearns, Swami Swaminathan, Douglas L. Mayers, Christina F. Spiropoulou, William A. Lee, Stuart T. Nichol, Tomas Cihlar () and Sina Bavari ()
Additional contact information
Travis K. Warren: United States Army Medical Research Institute of Infectious Diseases
Robert Jordan: Gilead Sciences
Michael K. Lo: Centers for Disease Control and Prevention
Adrian S. Ray: Gilead Sciences
Richard L. Mackman: Gilead Sciences
Veronica Soloveva: United States Army Medical Research Institute of Infectious Diseases
Dustin Siegel: Gilead Sciences
Michel Perron: Gilead Sciences
Roy Bannister: Gilead Sciences
Hon C. Hui: Gilead Sciences
Nate Larson: Gilead Sciences
Robert Strickley: Gilead Sciences
Jay Wells: United States Army Medical Research Institute of Infectious Diseases
Kelly S. Stuthman: United States Army Medical Research Institute of Infectious Diseases
Sean A. Van Tongeren: United States Army Medical Research Institute of Infectious Diseases
Nicole L. Garza: United States Army Medical Research Institute of Infectious Diseases
Ginger Donnelly: United States Army Medical Research Institute of Infectious Diseases
Amy C. Shurtleff: United States Army Medical Research Institute of Infectious Diseases
Cary J. Retterer: United States Army Medical Research Institute of Infectious Diseases
Dima Gharaibeh: United States Army Medical Research Institute of Infectious Diseases
Rouzbeh Zamani: United States Army Medical Research Institute of Infectious Diseases
Tara Kenny: United States Army Medical Research Institute of Infectious Diseases
Brett P. Eaton: United States Army Medical Research Institute of Infectious Diseases
Elizabeth Grimes: United States Army Medical Research Institute of Infectious Diseases
Lisa S. Welch: United States Army Medical Research Institute of Infectious Diseases
Laura Gomba: United States Army Medical Research Institute of Infectious Diseases
Catherine L. Wilhelmsen: United States Army Medical Research Institute of Infectious Diseases
Donald K. Nichols: United States Army Medical Research Institute of Infectious Diseases
Jonathan E. Nuss: United States Army Medical Research Institute of Infectious Diseases
Elyse R. Nagle: United States Army Medical Research Institute of Infectious Diseases
Jeffrey R. Kugelman: United States Army Medical Research Institute of Infectious Diseases
Gustavo Palacios: United States Army Medical Research Institute of Infectious Diseases
Edward Doerffler: Gilead Sciences
Sean Neville: Gilead Sciences
Ernest Carra: Gilead Sciences
Michael O. Clarke: Gilead Sciences
Lijun Zhang: Gilead Sciences
Willard Lew: Gilead Sciences
Bruce Ross: Gilead Sciences
Queenie Wang: Gilead Sciences
Kwon Chun: Gilead Sciences
Lydia Wolfe: Gilead Sciences
Darius Babusis: Gilead Sciences
Yeojin Park: Gilead Sciences
Kirsten M. Stray: Gilead Sciences
Iva Trancheva: Gilead Sciences
Joy Y. Feng: Gilead Sciences
Ona Barauskas: Gilead Sciences
Yili Xu: Gilead Sciences
Pamela Wong: Gilead Sciences
Molly R. Braun: Boston University School of Medicine
Mike Flint: Centers for Disease Control and Prevention
Laura K. McMullan: Centers for Disease Control and Prevention
Shan-Shan Chen: Gilead Sciences
Rachel Fearns: Boston University School of Medicine
Swami Swaminathan: Gilead Sciences
Douglas L. Mayers: United States Army Medical Research Institute of Infectious Diseases
Christina F. Spiropoulou: Centers for Disease Control and Prevention
William A. Lee: Gilead Sciences
Stuart T. Nichol: Centers for Disease Control and Prevention
Tomas Cihlar: Gilead Sciences
Sina Bavari: United States Army Medical Research Institute of Infectious Diseases

Nature, 2016, vol. 531, issue 7594, 381-385

Abstract: The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.

Date: 2016
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DOI: 10.1038/nature17180

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