Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons

A. R. Mardinly, I. Spiegel, A. Patrizi, E. Centofante, J. E. Bazinet, C. P. Tzeng, C. Mandel-Brehm, D. A. Harmin, H. Adesnik, M. Fagiolini and M. E. Greenberg ()
Additional contact information
A. R. Mardinly: University of California Berkeley
I. Spiegel: Harvard Medical School
A. Patrizi: FM Kirby Neurobiology Center, Boston Children’s Hospital
E. Centofante: FM Kirby Neurobiology Center, Boston Children’s Hospital
J. E. Bazinet: Harvard Medical School
C. P. Tzeng: Harvard Medical School
C. Mandel-Brehm: Harvard Medical School
D. A. Harmin: Harvard Medical School
H. Adesnik: University of California Berkeley
M. Fagiolini: FM Kirby Neurobiology Center, Boston Children’s Hospital
M. E. Greenberg: Harvard Medical School

Nature, 2016, vol. 531, issue 7594, 371-375

Abstract: Igf1 is identified in mice as an experience-induced gene that functions cell-autonomously to increase inhibitory input onto a disinhibitory subtype of GABAergic neurons in the cortex, affecting the downstream excitation–inhibition balance within circuits that regulate visual acuity, and providing a novel example of experience modulating neural plasticity.

Date: 2016
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DOI: 10.1038/nature17187

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