Visualization of immediate immune responses to pioneer metastatic cells in the lung

Mark B. Headley, Adriaan Bins, Alyssa Nip, Edward W. Roberts, Mark R. Looney, Audrey Gerard and Matthew F. Krummel ()
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Mark B. Headley: University of California
Adriaan Bins: University of California
Alyssa Nip: University of California
Edward W. Roberts: University of California
Mark R. Looney: University of California
Audrey Gerard: University of California
Matthew F. Krummel: University of California

Nature, 2016, vol. 531, issue 7595, 513-517

Abstract: Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.

Date: 2016
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DOI: 10.1038/nature16985

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