Melanoma addiction to the long non-coding RNA SAMMSON

Eleonora Leucci, Roberto Vendramin, Marco Spinazzi, Patrick Laurette, Mark Fiers, Jasper Wouters, Enrico Radaelli, Sven Eyckerman, Carina Leonelli, Katrien Vanderheyden, Aljosja Rogiers, Els Hermans, Pieter Baatsen, Stein Aerts, Frederic Amant, Stefan Van Aelst, Joost van den Oord, Bart de Strooper, Irwin Davidson, Denis L. J. Lafontaine, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh and Jean-Christophe Marine ()
Additional contact information
Eleonora Leucci: Laboratory For Molecular Cancer Biology, Center for Human Genetics
Roberto Vendramin: Laboratory For Molecular Cancer Biology, Center for Human Genetics
Marco Spinazzi: Center for the Biology of Disease, VIB
Patrick Laurette: Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC)
Mark Fiers: Center for the Biology of Disease, VIB
Jasper Wouters: Laboratory of Translational Cell and Tissue Research
Enrico Radaelli: Mouse Histopathology Core Facility, Center for the Biology of Disease
Sven Eyckerman: Medical Biotechnology Center, VIB
Carina Leonelli: Center for Medical Genetics, Gent University
Katrien Vanderheyden: Center for Medical Genetics, Gent University
Aljosja Rogiers: Laboratory For Molecular Cancer Biology, Center for Human Genetics
Els Hermans: Gynaecologische Oncologie, KU Leuven
Pieter Baatsen: Center for the Biology of Disease, VIB
Stein Aerts: Laboratory of Computational Biology, Center for Human Genetics
Frederic Amant: Gynaecologische Oncologie, KU Leuven
Stefan Van Aelst: Computer Science and Statistics, Gent University
Joost van den Oord: Laboratory of Translational Cell and Tissue Research
Bart de Strooper: Center for the Biology of Disease, VIB
Irwin Davidson: Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC)
Denis L. J. Lafontaine: RNA Molecular Biology, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB)
Kris Gevaert: Medical Biotechnology Center, VIB
Jo Vandesompele: Center for Medical Genetics, Gent University
Pieter Mestdagh: Center for Medical Genetics, Gent University
Jean-Christophe Marine: Laboratory For Molecular Cancer Biology, Center for Human Genetics

Nature, 2016, vol. 531, issue 7595, 518-522

Abstract: A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy.

Date: 2016
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DOI: 10.1038/nature17161

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