The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Rajesh Ravindran, Jens Loebbermann, Helder I. Nakaya, Nooruddin Khan, Hualing Ma, Leonardo Gama, Deepa K. Machiah, Benton Lawson, Paul Hakimpour, Yi-chong Wang, Shuzhao Li, Prachi Sharma, Randal J. Kaufman, Jennifer Martinez and Bali Pulendran ()
Additional contact information
Rajesh Ravindran: Emory Vaccine Center, Yerkes National Primate Research Center
Jens Loebbermann: Emory Vaccine Center, Yerkes National Primate Research Center
Helder I. Nakaya: School of Pharmaceutical Sciences, University of São Paulo
Nooruddin Khan: School of Life Sciences, University of Hyderabad
Hualing Ma: Emory Vaccine Center, Yerkes National Primate Research Center
Leonardo Gama: School of Pharmaceutical Sciences, University of São Paulo
Deepa K. Machiah: Yerkes National Primate Research Center
Benton Lawson: Virology Core, Emory Vaccine Center and Yerkes National Primate Research Center
Paul Hakimpour: Emory Vaccine Center, Yerkes National Primate Research Center
Yi-chong Wang: Emory Vaccine Center, Yerkes National Primate Research Center
Shuzhao Li: Emory Vaccine Center, Yerkes National Primate Research Center
Prachi Sharma: Yerkes National Primate Research Center
Randal J. Kaufman: Degenerative Disease Program, Sanford Burnham Prebys Medical Discovery Institute
Jennifer Martinez: National Institute of Environmental Health Sciences
Bali Pulendran: Emory Vaccine Center, Yerkes National Primate Research Center

Nature, 2016, vol. 531, issue 7595, 523-527

Abstract: The GCN2 kinase is shown to have a protective role in the regulation of intestinal inflammation during amino acid starvation in a mouse model of colitis.

Date: 2016
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DOI: 10.1038/nature17186

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