Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making

Kelly A. Zalocusky, Charu Ramakrishnan, Talia N. Lerner, Thomas J. Davidson, Brian Knutson and Karl Deisseroth ()
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Kelly A. Zalocusky: Stanford University
Charu Ramakrishnan: Stanford University
Talia N. Lerner: Stanford University
Thomas J. Davidson: Stanford University
Karl Deisseroth: Stanford University

Nature, 2016, vol. 531, issue 7596, 642-646

Abstract: Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.

Date: 2016
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DOI: 10.1038/nature17400

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