Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young and Rudolf Jaenisch ()
Additional contact information
Frank Soldner: The Whitehead Institute
Yonatan Stelzer: The Whitehead Institute
Chikdu S. Shivalila: The Whitehead Institute
Brian J. Abraham: The Whitehead Institute
Jeanne C. Latourelle: Boston University School of Medicine
M. Inmaculada Barrasa: The Whitehead Institute
Johanna Goldmann: The Whitehead Institute
Richard H. Myers: Boston University School of Medicine
Richard A. Young: The Whitehead Institute
Rudolf Jaenisch: The Whitehead Institute

Nature, 2016, vol. 533, issue 7601, 95-99

Abstract: A CRISPR/Cas9 system is used to dissect the role of allelic risk variants on the expression of the α-synuclein gene SNCA, which has been linked to Parkinson’s disease development.

Date: 2016
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DOI: 10.1038/nature17939

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