Unique human immune signature of Ebola virus disease in Guinea

Paula Ruibal, Lisa Oestereich, Anja Lüdtke, Beate Becker-Ziaja, David M. Wozniak, Romy Kerber, Miša Korva, Mar Cabeza-Cabrerizo, Joseph A. Bore, Fara Raymond Koundouno, Sophie Duraffour, Romy Weller, Anja Thorenz, Eleonora Cimini, Domenico Viola, Chiara Agrati, Johanna Repits, Babak Afrough, Lauren A. Cowley, Didier Ngabo, Julia Hinzmann, Marc Mertens, Inês Vitoriano, Christopher H. Logue, Jan Peter Boettcher, Elisa Pallasch, Andreas Sachse, Amadou Bah, Katja Nitzsche, Eeva Kuisma, Janine Michel, Tobias Holm, Elsa-Gayle Zekeng, Isabel García-Dorival, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Thomas Strecker, Antonino Di Caro, Tatjana Avšič-Županc, Andreas Kurth, Silvia Meschi, Stephane Mély, Edmund Newman, Anne Bocquin, Zoltan Kis, Anne Kelterbaum, Peter Molkenthin, Fabrizio Carletti, Jasmine Portmann, Svenja Wolff, Concetta Castilletti, Gordian Schudt, Alexandra Fizet, Lisa J. Ottowell, Eva Herker, Thomas Jacobs, Birte Kretschmer, Ettore Severi, Nobila Ouedraogo, Mar Lago, Anabel Negredo, Leticia Franco, Pedro Anda, Stefan Schmiedel, Benno Kreuels, Dominic Wichmann, Marylyn M. Addo, Ansgar W. Lohse, Hilde De Clerck, Carolina Nanclares, Sylvie Jonckheere, Michel Van Herp, Armand Sprecher, Gao Xiaojiang, Mary Carrington, Osvaldo Miranda, Carlos M. Castro, Martin Gabriel, Patrick Drury, Pierre Formenty, Boubacar Diallo, Lamine Koivogui, N’Faly Magassouba, Miles W. Carroll, Stephan Günther () and César Muñoz-Fontela ()
Additional contact information
Paula Ruibal: Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Lisa Oestereich: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Anja Lüdtke: Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Beate Becker-Ziaja: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
David M. Wozniak: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Romy Kerber: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Miša Korva: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Mar Cabeza-Cabrerizo: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Joseph A. Bore: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Fara Raymond Koundouno: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Sophie Duraffour: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Romy Weller: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Anja Thorenz: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Eleonora Cimini: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Domenico Viola: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Chiara Agrati: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Johanna Repits: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Babak Afrough: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Lauren A. Cowley: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Didier Ngabo: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Julia Hinzmann: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Marc Mertens: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Inês Vitoriano: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Christopher H. Logue: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Jan Peter Boettcher: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Elisa Pallasch: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Andreas Sachse: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Amadou Bah: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Katja Nitzsche: German Center for Infection Research (DZIF)
Eeva Kuisma: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Janine Michel: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Tobias Holm: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Elsa-Gayle Zekeng: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Isabel García-Dorival: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Roman Wölfel: German Center for Infection Research (DZIF)
Kilian Stoecker: German Center for Infection Research (DZIF)
Erna Fleischmann: German Center for Infection Research (DZIF)
Thomas Strecker: German Center for Infection Research (DZIF)
Antonino Di Caro: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Tatjana Avšič-Županc: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Andreas Kurth: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Silvia Meschi: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Stephane Mély: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Edmund Newman: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Anne Bocquin: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Zoltan Kis: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Anne Kelterbaum: German Center for Infection Research (DZIF)
Peter Molkenthin: German Center for Infection Research (DZIF)
Fabrizio Carletti: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Jasmine Portmann: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Svenja Wolff: German Center for Infection Research (DZIF)
Concetta Castilletti: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Gordian Schudt: German Center for Infection Research (DZIF)
Alexandra Fizet: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Lisa J. Ottowell: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Eva Herker: Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Thomas Jacobs: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Birte Kretschmer: Eurice, European Research and Project Office
Ettore Severi: European Centre for Disease Prevention and Control
Nobila Ouedraogo: Robert Koch Institute
Mar Lago: Infectious Diseases Unit, Internal Medicine Service, Hospital La Paz
Anabel Negredo: National Center of Microbiology, Institute of Health ‘Carlos III’
Leticia Franco: National Center of Microbiology, Institute of Health ‘Carlos III’
Pedro Anda: National Center of Microbiology, Institute of Health ‘Carlos III’
Stefan Schmiedel: University Medical Center Hamburg-Eppendorf
Benno Kreuels: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Dominic Wichmann: German Center for Infection Research (DZIF)
Marylyn M. Addo: German Center for Infection Research (DZIF)
Ansgar W. Lohse: German Center for Infection Research (DZIF)
Hilde De Clerck: Médecins sans Frontières
Carolina Nanclares: Médecins sans Frontières
Sylvie Jonckheere: Médecins sans Frontières
Michel Van Herp: Médecins sans Frontières
Armand Sprecher: Médecins sans Frontières
Gao Xiaojiang: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research
Mary Carrington: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research
Osvaldo Miranda: Hospital Militar Central Dr. Carlos J. Finlay
Carlos M. Castro: Hospital Militar Central Dr. Carlos J. Finlay
Martin Gabriel: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
Patrick Drury: World Health Organization
Pierre Formenty: World Health Organization
Boubacar Diallo: World Health Organization
Lamine Koivogui: Institut National de Santé Publique
N’Faly Magassouba: Université Gamal Abdel Nasser de Conakry
Miles W. Carroll: European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
Stephan Günther: Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
César Muñoz-Fontela: Heinrich Pette Institute, Leibniz Institute for Experimental Virology

Nature, 2016, vol. 533, issue 7601, 100-104

Abstract: Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature17949 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:533:y:2016:i:7601:d:10.1038_nature17949

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature17949

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().