RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Jennifer Martinez (), Larissa D. Cunha, Sunmin Park, Mao Yang, Qun Lu, Robert Orchard, Quan-Zhen Li, Mei Yan, Laura Janke, Cliff Guy, Andreas Linkermann, Herbert W. Virgin and Douglas R. Green ()
Additional contact information
Jennifer Martinez: St Jude Children's Research Hospital
Larissa D. Cunha: St Jude Children's Research Hospital
Sunmin Park: Washington University School of Medicine
Mao Yang: St Jude Children's Research Hospital
Qun Lu: Washington University School of Medicine
Robert Orchard: Washington University School of Medicine
Quan-Zhen Li: University of Texas Southwestern Medical Center
Mei Yan: University of Texas Southwestern Medical Center
Laura Janke: St Jude Children's Research Hospital
Cliff Guy: St Jude Children's Research Hospital
Andreas Linkermann: Christian-Albrechts-University
Herbert W. Virgin: Washington University School of Medicine
Douglas R. Green: St Jude Children's Research Hospital

Nature, 2016, vol. 533, issue 7601, 115-119

Abstract: Defects in LC3-associated phagocytosis in mice are shown to result in systemic lupus erythematosus-like disease; dying cells are engulfed but not degraded in LAP-deficient mice, resulting in increased serum levels of autoantibodies and inflammatory cytokines, and evidence of kidney disease.

Date: 2016
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DOI: 10.1038/nature17950

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