Extra-helical binding site of a glucagon receptor antagonist

Ali Jazayeri, Andrew S. Doré, Daniel Lamb, Harini Krishnamurthy, Stacey M. Southall, Asma H. Baig, Andrea Bortolato, Markus Koglin, Nathan J. Robertson, James C. Errey, Stephen P. Andrews, Iryna Teobald, Alastair J. H. Brown, Robert M. Cooke, Malcolm Weir and Fiona H. Marshall ()
Additional contact information
Ali Jazayeri: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Andrew S. Doré: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Daniel Lamb: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Harini Krishnamurthy: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Stacey M. Southall: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Asma H. Baig: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Andrea Bortolato: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Markus Koglin: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Nathan J. Robertson: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
James C. Errey: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Stephen P. Andrews: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Iryna Teobald: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Alastair J. H. Brown: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Robert M. Cooke: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Malcolm Weir: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Fiona H. Marshall: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City

Nature, 2016, vol. 533, issue 7602, 274-277

Abstract: The X-ray crystal structure of the transmembrane portion of the human glucagon receptor, a class B G-protein-coupled receptor (GPCR), is solved in the presence of the antagonist MK-0893, with potential implications for the development of therapeutics that target other class B GPCRs.

Date: 2016
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DOI: 10.1038/nature17414

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