Architecture of the mitochondrial calcium uniporter

Kirill Oxenoid, Ying Dong, Chan Cao, Tanxing Cui, Yasemin Sancak, Andrew L. Markhard, Zenon Grabarek, Liangliang Kong, Zhijun Liu, Bo Ouyang, Yao Cong, Vamsi K. Mootha and James J. Chou ()
Additional contact information
Kirill Oxenoid: Harvard Medical School
Ying Dong: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Science Research Center, Chinese Academy of Sciences
Chan Cao: Harvard Medical School
Tanxing Cui: Harvard Medical School
Yasemin Sancak: Massachusetts General Hospital
Andrew L. Markhard: Massachusetts General Hospital
Zenon Grabarek: Massachusetts General Hospital
Liangliang Kong: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Science Research Center, Chinese Academy of Sciences
Zhijun Liu: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Science Research Center, Chinese Academy of Sciences
Bo Ouyang: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Science Research Center, Chinese Academy of Sciences
Yao Cong: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Science Research Center, Chinese Academy of Sciences
Vamsi K. Mootha: Massachusetts General Hospital
James J. Chou: Harvard Medical School

Nature, 2016, vol. 533, issue 7602, 269-273

Abstract: The structure of the core region of the mitochondrial calcium uniporter (MCU) is determined by NMR and electron microscopy, revealing that MCU is a homo-pentamer with a specific transmembrane helix forming a hydrophilic pore across the membrane, and representing one of the largest membrane protein structures characterized by NMR spectroscopy.

Date: 2016
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DOI: 10.1038/nature17656

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