Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst () and R. Scott Prosser ()
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Libin Ye: University of Toronto, UTM
Ned Van Eps: University of Toronto
Marco Zimmer: University of Toronto
Oliver P. Ernst: University of Toronto
R. Scott Prosser: University of Toronto, UTM

Nature, 2016, vol. 533, issue 7602, 265-268

Abstract: The adenosine A2A receptor, a class A G-protein-coupled receptor, exists as an ensemble of two inactive and two active states in equilibrium and is activated by conformational selection rather than induced fit.

Date: 2016
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DOI: 10.1038/nature17668

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