Molecular mechanism of APC/C activation by mitotic phosphorylation

Suyang Zhang, Leifu Chang, Claudio Alfieri, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel and David Barford ()
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Suyang Zhang: MRC Laboratory of Molecular Biology
Leifu Chang: MRC Laboratory of Molecular Biology
Claudio Alfieri: MRC Laboratory of Molecular Biology
Ziguo Zhang: MRC Laboratory of Molecular Biology
Jing Yang: MRC Laboratory of Molecular Biology
Sarah Maslen: MRC Laboratory of Molecular Biology
Mark Skehel: MRC Laboratory of Molecular Biology
David Barford: MRC Laboratory of Molecular Biology

Nature, 2016, vol. 533, issue 7602, 260-264

Abstract: Phosphorylation of the anaphase-promoting complex (APC/C) allows for its control by the co-activator Cdc20; a mechanism that has relevance to understanding the control of other large multimeric complexes by phosphorylation.

Date: 2016
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DOI: 10.1038/nature17973

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