An obligatory role for neurotensin in high-fat-diet-induced obesity

Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang Jia and B. Mark Evers ()
Additional contact information
Jing Li: University of Kentucky
Jun Song: University of Kentucky
Yekaterina Y. Zaytseva: Markey Cancer Center, University of Kentucky
Yajuan Liu: Markey Cancer Center, University of Kentucky
Piotr Rychahou: University of Kentucky
Kai Jiang: Markey Cancer Center, University of Kentucky
Marlene E. Starr: University of Kentucky
Ji Tae Kim: University of Kentucky
Jennifer W. Harris: University of Kentucky
Frederique B. Yiannikouris: University of Kentucky
Wendy S. Katz: University of Kentucky
Peter M. Nilsson: Lund University
Marju Orho-Melander: Lund University
Jing Chen: University of Kentucky
Haining Zhu: University of Kentucky
Timothy Fahrenholz: Markey Cancer Center, University of Kentucky
Richard M. Higashi: Markey Cancer Center, University of Kentucky
Tianyan Gao: Markey Cancer Center, University of Kentucky
Andrew J. Morris: Gill Heart Institute, University of Kentucky and Lexington Veterans Affairs Medical Center
Lisa A. Cassis: University of Kentucky
Teresa W. -M. Fan: Markey Cancer Center, University of Kentucky
Heidi L. Weiss: Markey Cancer Center, University of Kentucky
Paul R. Dobner: University of Massachusetts Medical School
Olle Melander: Lund University
Jianhang Jia: Markey Cancer Center, University of Kentucky
B. Mark Evers: University of Kentucky

Nature, 2016, vol. 533, issue 7603, 411-415

Abstract: Neurotensin, a peptide expressed in the enteroendocrine cells of the small intestine that is released upon fat ingestion, is shown to increase fatty acid absorption, with neurotensin-deficient mice being protected from obesity induced by a high-fat diet.

Date: 2016
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DOI: 10.1038/nature17662

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