Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris and David R. Liu ()
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Alexis C. Komor: Harvard University
Yongjoo B. Kim: Harvard University
Michael S. Packer: Harvard University
John A. Zuris: Harvard University
David R. Liu: Harvard University

Nature, 2016, vol. 533, issue 7603, 420-424

Abstract: CRISPR/Cas9 DNA editing creates a double-stranded break in the target DNA, which can frequently generate random insertion or deletion of bases (indels); a new genome editing approach combining Cas9 with a cytidine deaminase is described here, which corrects point mutations more efficiently than canonical Cas9, while avoiding double-stranded breaks and indel formation.

Date: 2016
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DOI: 10.1038/nature17946

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