FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration

Eugeniu Nacu (), Elena Gromberg, Catarina R. Oliveira, David Drechsel and Elly M. Tanaka ()
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Eugeniu Nacu: DFG Research Center for Regenerative Therapies, Technische Universität Dresden
Elena Gromberg: DFG Research Center for Regenerative Therapies, Technische Universität Dresden
Catarina R. Oliveira: DFG Research Center for Regenerative Therapies, Technische Universität Dresden
David Drechsel: Max Planck Institute of Molecular Cell Biology and Genetics
Elly M. Tanaka: DFG Research Center for Regenerative Therapies, Technische Universität Dresden

Nature, 2016, vol. 533, issue 7603, 407-410

Abstract: The long-standing puzzle of why salamander limb regeneration requires anterior and posterior tissue interaction has been solved by the demonstration that fibroblast growth factor 8 and sonic hedgehog are key anterior and posterior cross-inductive signals that drive regeneration.

Date: 2016
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DOI: 10.1038/nature17972

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