Structure of the thermally stable Zika virus

Victor A. Kostyuchenko, Elisa X. Y. Lim, Shuijun Zhang, Guntur Fibriansah, Thiam-Seng Ng, Justin S. G. Ooi, Jian Shi and Shee-Mei Lok ()
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Victor A. Kostyuchenko: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Elisa X. Y. Lim: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Shuijun Zhang: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Guntur Fibriansah: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Thiam-Seng Ng: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Justin S. G. Ooi: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Jian Shi: Centre for BioImaging Sciences, National University of Singapore
Shee-Mei Lok: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School

Nature, 2016, vol. 533, issue 7603, 425-428

Abstract: The 3.7 Å cryo-electron microscopy structure of Zika virus is presented, revealing a typical flavivirus architecture; in contrast to the related flavivirus dengue virus, Zika virus is thermally stable at 40 °C, and this structural stability may be a feature that helps it to survive in semen, saliva and urine.

Date: 2016
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DOI: 10.1038/nature17994

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