Local fitness landscape of the green fluorescent protein

Karen S. Sarkisyan, Dmitry A. Bolotin, Margarita V. Meer, Dinara R. Usmanova, Alexander S. Mishin, George V. Sharonov, Dmitry N. Ivankov, Nina G. Bozhanova, Mikhail S. Baranov, Onuralp Soylemez, Natalya S. Bogatyreva, Peter K. Vlasov, Evgeny S. Egorov, Maria D. Logacheva, Alexey S. Kondrashov, Dmitry M. Chudakov, Ekaterina V. Putintseva, Ilgar Z. Mamedov, Dan S. Tawfik, Konstantin A. Lukyanov and Fyodor A. Kondrashov ()
Additional contact information
Karen S. Sarkisyan: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Dmitry A. Bolotin: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Margarita V. Meer: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Dinara R. Usmanova: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Alexander S. Mishin: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
George V. Sharonov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Dmitry N. Ivankov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Nina G. Bozhanova: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Mikhail S. Baranov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Onuralp Soylemez: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Natalya S. Bogatyreva: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Peter K. Vlasov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Evgeny S. Egorov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Maria D. Logacheva: Pirogov Russian National Research Medical University
Alexey S. Kondrashov: Moscow State University
Dmitry M. Chudakov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Ekaterina V. Putintseva: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Ilgar Z. Mamedov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Dan S. Tawfik: Weizmann Institute of Science
Konstantin A. Lukyanov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Fyodor A. Kondrashov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology

Nature, 2016, vol. 533, issue 7603, 397-401

Abstract: Comprehensive genotype–phenotype mapping of the green fluorescent protein shows that the local fitness peak is narrow, shaped by a high prevalence of epistatic interactions, providing for the loss of fluorescence when the joint effect of mutations exceeds a threshold.

Date: 2016
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DOI: 10.1038/nature17995

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