Crystal structure of the human sterol transporter ABCG5/ABCG8

Jyh-Yeuan Lee, Lisa N. Kinch, Dominika M. Borek, Jin Wang, Junmei Wang, Ina L. Urbatsch, Xiao-Song Xie, Nikolai V. Grishin, Jonathan C. Cohen, Zbyszek Otwinowski, Helen H. Hobbs () and Daniel M. Rosenbaum ()
Additional contact information
Jyh-Yeuan Lee: Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
Lisa N. Kinch: University of Texas Southwestern Medical Center
Dominika M. Borek: University of Texas Southwestern Medical Center
Jin Wang: Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
Junmei Wang: Cecil & Ida Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center
Ina L. Urbatsch: Texas Tech University Health Sciences Center
Xiao-Song Xie: Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
Nikolai V. Grishin: University of Texas Southwestern Medical Center
Jonathan C. Cohen: Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
Zbyszek Otwinowski: University of Texas Southwestern Medical Center
Helen H. Hobbs: Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
Daniel M. Rosenbaum: University of Texas Southwestern Medical Center

Nature, 2016, vol. 533, issue 7604, 561-564

Abstract: The X-ray structure of human ABCG5/ABCG8 heterodimer in a nucleotide-free state, being the first atomic model of an ABC sterol transporter.

Date: 2016
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DOI: 10.1038/nature17666

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