Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Tamer Sallam, Marius C. Jones, Thomas Gilliland, Li Zhang, Xiaohui Wu, Ascia Eskin, Jaspreet Sandhu, David Casero, Thomas Q. de Aguiar Vallim, Cynthia Hong, Melanie Katz, Richard Lee, Julian Whitelegge and Peter Tontonoz ()
Additional contact information
Tamer Sallam: Howard Hughes Medical Institute, University of California
Marius C. Jones: Howard Hughes Medical Institute, University of California
Thomas Gilliland: Howard Hughes Medical Institute, University of California
Li Zhang: Howard Hughes Medical Institute, University of California
Xiaohui Wu: Howard Hughes Medical Institute, University of California
Ascia Eskin: Departement of Human Genetics, University of California
Jaspreet Sandhu: Howard Hughes Medical Institute, University of California
David Casero: Howard Hughes Medical Institute, University of California
Thomas Q. de Aguiar Vallim: University of California
Cynthia Hong: Howard Hughes Medical Institute, University of California
Melanie Katz: Ionis Pharmaceuticals
Richard Lee: Ionis Pharmaceuticals
Julian Whitelegge: Pasarow Mass Spectrometry Laboratory, NPI-Semel Institute, University of California
Peter Tontonoz: Howard Hughes Medical Institute, University of California

Nature, 2016, vol. 534, issue 7605, 124-128

Abstract: The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis, which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.

Date: 2016
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DOI: 10.1038/nature17674

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