Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury

Ge Tao, Peter C. Kahr, Yuka Morikawa, Min Zhang, Mahdis Rahmani, Todd R. Heallen, Lele Li, Zhao Sun, Eric N. Olson, Brad A. Amendt and James F. Martin ()
Additional contact information
Ge Tao: Baylor College of Medicine
Peter C. Kahr: Baylor College of Medicine
Yuka Morikawa: Texas Heart Institute
Min Zhang: Baylor College of Medicine
Mahdis Rahmani: Texas Heart Institute
Todd R. Heallen: Texas Heart Institute
Lele Li: Baylor College of Medicine
Zhao Sun: The University of Iowa
Eric N. Olson: University of Texas Southwestern Medical Center
Brad A. Amendt: The University of Iowa
James F. Martin: Baylor College of Medicine

Nature, 2016, vol. 534, issue 7605, 119-123

Abstract: The transcription factor Pitx2 is upregulated in injured neonatal and Hippo-deficient mouse hearts, where it interacts with the Hippo effector protein Yap to activate reactive oxygen species scavengers, thus preventing the heart from oxidative damage.

Date: 2016
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DOI: 10.1038/nature17959

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