Ribosome-dependent activation of stringent control

Alan Brown, Israel S. Fernández, Yuliya Gordiyenko and V. Ramakrishnan ()
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Alan Brown: MRC Laboratory of Molecular Biology
Israel S. Fernández: MRC Laboratory of Molecular Biology
Yuliya Gordiyenko: MRC Laboratory of Molecular Biology
V. Ramakrishnan: MRC Laboratory of Molecular Biology

Nature, 2016, vol. 534, issue 7606, 277-280

Abstract: The structure of a bacterial ribosome–RelA complex reveals that RelA, a protein recruited to the ribosome in the case of scarce amino acids, binds in a different location to translation factors, and that this binding event suppresses auto-inhibition to activate synthesis of the (p)ppGpp secondary messenger, thus initiating stringent control.

Date: 2016
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DOI: 10.1038/nature17675

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