Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Vanessa S. Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Chris J. Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina, Derek G. Barratt, Sabina Cosulich, Teresa Klinowska, Neal Rosen () and Kevan M. Shokat ()
Additional contact information
Vanessa S. Rodrik-Outmezguine: Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
Masanori Okaniwa: University of California San Francisco
Zhan Yao: Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
Chris J. Novotny: University of California San Francisco
Claire McWhirter: AstraZeneca, Alderley Park
Arpitha Banaji: Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
Helen Won: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Wai Wong: Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center
Mike Berger: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Elisa de Stanchina: Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center
Derek G. Barratt: AstraZeneca, Alderley Park
Sabina Cosulich: AstraZeneca, Alderley Park
Teresa Klinowska: AstraZeneca, Alderley Park
Neal Rosen: Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
Kevan M. Shokat: University of California San Francisco

Nature, 2016, vol. 534, issue 7606, 272-276

Abstract: Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.

Date: 2016
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DOI: 10.1038/nature17963

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