The Brazilian Zika virus strain causes birth defects in experimental models

Fernanda R. Cugola, Isabella R. Fernandes, Fabiele B. Russo, Beatriz C. Freitas, João L. M. Dias, Katia P. Guimarães, Cecília Benazzato, Nathalia Almeida, Graciela C. Pignatari, Sarah Romero, Carolina M. Polonio, Isabela Cunha, Carla L. Freitas, Wesley N. Brandão, Cristiano Rossato, David G. Andrade, Daniele de P. Faria, Alexandre T. Garcez, Carlos A. Buchpigel, Carla T. Braconi, Erica Mendes, Amadou A. Sall, Paolo M. de A. Zanotto, Jean Pierre S. Peron (), Alysson R. Muotri () and Patricia C. B. Beltrão-Braga ()
Additional contact information
Fernanda R. Cugola: University of São Paulo, Stem Cell Laboratory
Isabella R. Fernandes: University of São Paulo, Stem Cell Laboratory
Fabiele B. Russo: University of São Paulo, Stem Cell Laboratory
Beatriz C. Freitas: University of California San Diego, School of Medicine, Stem Cell Program
João L. M. Dias: University of São Paulo, Stem Cell Laboratory
Katia P. Guimarães: University of São Paulo, Stem Cell Laboratory
Cecília Benazzato: University of São Paulo, Stem Cell Laboratory
Nathalia Almeida: University of São Paulo, Stem Cell Laboratory
Graciela C. Pignatari: University of São Paulo, Stem Cell Laboratory
Sarah Romero: University of California San Diego, School of Medicine, Stem Cell Program
Carolina M. Polonio: University of São Paulo, Neuroimmune Interactions Laboratory
Isabela Cunha: University of São Paulo, Neuroimmune Interactions Laboratory
Carla L. Freitas: University of São Paulo, Neuroimmune Interactions Laboratory
Wesley N. Brandão: University of São Paulo, Neuroimmune Interactions Laboratory
Cristiano Rossato: University of São Paulo, Neuroimmune Interactions Laboratory
David G. Andrade: University of São Paulo, Neuroimmune Interactions Laboratory
Daniele de P. Faria: University of São Paulo, USP School of Medicine
Alexandre T. Garcez: University of São Paulo, USP School of Medicine
Carlos A. Buchpigel: University of São Paulo, USP School of Medicine
Carla T. Braconi: University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics
Erica Mendes: University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics
Amadou A. Sall: Institute Pasteur in Dakar
Paolo M. de A. Zanotto: University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics
Jean Pierre S. Peron: University of São Paulo, Neuroimmune Interactions Laboratory
Alysson R. Muotri: University of California San Diego, School of Medicine, Stem Cell Program
Patricia C. B. Beltrão-Braga: University of São Paulo, Stem Cell Laboratory

Nature, 2016, vol. 534, issue 7606, 267-271

Abstract: Brazilian Zika virus causes birth defects in mice Zika virus infection has been linked to an increase in the number of infants born with microcephaly in Brazil, but direct experimental proof that Zika virus causes birth defects was lacking. Here Alysson Muotri and colleagues show that the Brazilian Zika virus strain can cross the placenta and cause intrauterine growth restriction, including signs of microcephaly, in the SJL strain of mice. They also show that the virus can infect human brain organoids, inducing cell death by apoptosis and disrupting cortical layers.

Date: 2016
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DOI: 10.1038/nature18296

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